If you don’t need the information that’s stored in a data extension, you can delete it. When you delete a data extension, the information that it contains is also deleted and can't be accessed anymore.
Marketing Cloud Engagement temporarily retains information from a deleted data extension to ensure that current processes can access that information. During this period, you can’t create a data extension with the same name as the deleted data extension.
Don’t delete a data extension that’s assigned to a triggered send definition. If you do, the status of the triggered send definition changes to indicate an error.
important: You can’t delete a data extension if it has a data relationship to contact records or to another data extension. To delete a data extension that has a data relationship, first use Data Designer to remove the relationship, and then delete the data extension. See Data Designer in Salesforce Help.
Sample SOAP Envelope
<s:Envelope
xmlns:s="http://www.w3.org/2003/05/soap-envelope"
xmlns:a="http://schemas.xmlsoap.org/ws/2004/08/addressing"
xmlns:u="http://docs.oasis-open.org/wss/2004/01/oasis-200401-wss-wssecurity-utility-1.0.xsd">
<s:Header>
<a:Action s:mustUnderstand="1">Delete</a:Action>
<a:MessageID>urn:uuid:d5c8c2ee-384e-4492-af18-b01e0d438b62</a:MessageID>
<a:ReplyTo>
<a:Address>
http://schemas.xmlsoap.org/ws/2004/08/addressing/role/anonymous
</a:Address>
</a:ReplyTo>
<a:To s:mustUnderstand="1">
https://YOUR_SUBDOMAIN.soap.marketingcloudapis.com/Service.asmx
</a:To>
<o:Security
s:mustUnderstand="1"
xmlns:o="http://docs.oasis-open.org/wss/2004/01/oasis-200401-wss-wssecurity-secext-1.0.xsd">
<o:UsernameToken u:Id="uuid-c10e3bda-13ef-4868-bacd-6e760cd45cf2-1">
<o:Username>USERNAME</o:Username>
<o:Password>PASSWORD</o:Password>
</o:UsernameToken>
</o:Security>
</s:Header>
<s:Body
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xmlns:xsd="http://www.w3.org/2001/XMLSchema">
<DeleteRequest xmlns="http://exacttarget.com/wsdl/partnerAPI">
<Options></Options>
<Objects xsi:type="DataExtension">
<PartnerKey xsi:nil="true"></PartnerKey>
<ObjectID xsi:nil="true"></ObjectID>
<CustomerKey>External key of Data Extension</CustomerKey>
</Objects>
</DeleteRequest>
</s:Body>
</s:Envelope>