To make an asynchronous API call, identify it as asynchronous using one of these wrappers.
C# Example
<!-- Moved Gist inline (mc-doc/c2d43bb8cf52c43e651dfd4c111e753c) -->CreateOptions co = new CreateOptions();
co.RequestType = RequestType.Asynchronous;
co.RequestTypeSpecified = true;
CreateResult[] results = integrationFramework.Create(co, new APIObject[] { sub }, out requestID, out status);
<!-- Moved Gist inline (mc-doc/66ae6c4dbe60e592e8b92491101f2a9e) -->
SOAP Envelope
<soap:Body>
<CreateRequest xmlns="http://exacttarget.com/wsdl/partnerAPI">
<Options>
<RequestType>Asynchronous</RequestType>
</Options>
...